MELBOURNE, Australia (PNN) - March 23, 2017 - Scientists have made a discovery that could lead to a revolutionary drug that actually reverses aging.
The drug could help damaged DNA to miraculously repair and even protect NASA astronauts on Mars by protecting them from solar radiation.
A team of researchers developed the drug after discovering a key signaling process in DNA repair and cell aging.
During trials on mice, the team found that the drug directly repaired DNA damage caused by radiation exposure or old age.
“The cells of the old mice were indistinguishable from the young mice after just one week of treatment,” said lead author Professor David Sinclair.
Human trials of the pill will begin within six months.
“This is the closest we are to a safe and effective anti-aging drug that's perhaps only three to five years away from being on the market if the trials go well,” said Professor Sinclair.
The work has drawn the attention of NASA, which is considering the challenge of keeping its astronauts healthy during a four-year mission to Mars.
Even on short missions, astronauts experience accelerated aging from cosmic radiation, suffering from muscle weakness, memory loss, and other symptoms when they return.
On a trip to Mars, the situation would be far worse: Five percent of the astronauts' cells would die and their chances of cancer would approach 100%.
Professor Sinclair and his colleague Dr. Lindsay Wu were winners in NASA's iTech competition in December last year.
“We came in with a solution for a biological problem and it won the competition out of 300 entries,” said Dr. Wu.
Cosmic radiation is not only an issue for astronauts. We're all exposed to it aboard aircraft, with a London-Singapore-Melbourne flight roughly equivalent in radiation to a chest x-ray.
In theory, the anti-aging pill could mitigate any effects of DNA damage for frequent flyers.
The other group that could benefit from this work is survivors of childhood cancers.
Dr. Wu says 96% of childhood cancer survivors suffer a chronic illness by age 45, including cardiovascular disease, Type 2 diabetes, Alzheimer's disease, and cancers unrelated to the original cancer.
“All of this adds up to the fact they have accelerated aging, which is devastating,” he said. “It would be great to do something about that, and we believe we can with this molecule.”
The experiments in mice, from a team at the University of New South Wales, suggest a treatment for these issues is possible through a new drug.
While our cells can naturally repair DNA damage - such as damage caused by the sun - this ability declines with age.
The scientists identified that the call-signaling molecule NAD+, which is naturally present in every cell in the body, has a key role in protein interactions that control DNA repair.
Treating mice with an NAD+ “booster” called NMN improved their cells' ability to repair DNA damage caused by radiation exposure or aging.
For the past four years, Professor Sinclair and Dr. Wu have been working on making NMN into a drug substance with their companies MetroBiotech NSW and MetroBiotech International.
The human trials will begin this year at Brigham and Women's Hospital in Boston, Massachusetts.